Eli Lilly's Zepbound outperforms Novo Nordisk's Wegovy for weight loss in trial

- 5/11/2025

</head><body><p>(Reuters) -Eli Lilly said on Sunday its drug Zepbound was superior to Novo Nordisk's Wegovy across five weight-loss targets such as reducing waist circumference, citing data from a head-to-head trial.</p><p>Lilly reported in December that its obesity drug had already met the main goal, leading to 47% more weight loss than those who received Wegovy. Full data from the study was reported by the company in a press release and presented at the European Congress on Obesity.</p><p>The data is the first head-to-head trial comparing the wildly popular medicines, and gives Lilly more firepower as it seeks to gain wider insurance coverage in an obesity drug market estimated to reach more than $150 billion annually by the next decade.</p><p>It comes days after CVS Health's decision to drop Zepbound from some lists of medicines it covers for reimbursement, instead favoring Wegovy.</p><p>Zepbound helped nearly 25% more participants lose more than 15% of their weight compared to Wegovy, Lilly said on Sunday.</p><p>The trial also showed that treatment with Zepbound achieved a superior average waist circumference reduction of 18.4 centimeters (cm), while those treated with Wegovy saw an average reduction of 13 cm.</p><p>While Lilly's drug mimics two gut hormones to help reduce weight, Wegovy has a single mode of action.</p><p>U.S. approvals for Zepbound and Wegovy were based on separate trials in which Lilly's drug helped patients lose more than 22% of their weight after 72 weeks, while Wegovy led to 15% weight loss after 68 weeks.</p><p/><p> (Reporting by Christy Santhosh in Bengaluru; Editing by Leroy Leo)</p></body></html></p> <div id="news-wrapper"> <div class="thumbnail additional-resources client-content-image-box"> <div class="box-image" style="background-image: url(/images/home/news.jpg);"></div> <div class="caption"> <h3>Nationwide News</h3> <div> <p><a href='/mh/news-article-detail.aspx?id=155564'>NJ AG investigating after Fort Lee police shoot woman in ‘mental health crisis’</a></p> <p><a href='/mh/news-article-detail.aspx?id=155555'>How understaffing, mental health failures led to ‘mounting crisis’ in Richland County jail</a></p> <p><a href='/mh/news-archive.aspx'>News Archive</a></p> </div> </div> </div> </div> </div> </div> </div> </section> </div>  <footer class="footer">  <div class="clearfix footerInfo"> <div class="container"> <div class="row"> <div class="col-sm-7 col-xs-12"> <div class="footerText"> <a href="http://www.trilogyir.com/" target="_blank" class="footerLogo"><img src="/images/Noc-Logo-white.png" alt="Footer Logo" style="width: 200px;"></a> <div class="genericContent" id="landingPageText"> <p>The Network of Care for Mental/Behavioral Health is an online information portal for individuals, families and social service agencies concerned with community mental health services, substance use treatment programs and help for people with developmental disabilities.</p> </div> <h3 id="lblTechAssistance" style="color: #fff; 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Eli Lilly's Zepbound outperforms Novo Nordisk's Wegovy for weight loss in trial